Pyocyanin-induced mucin production is associated with redox modification of FOXA2
نویسندگان
چکیده
منابع مشابه
Pyocyanin-induced mucin production is associated with redox modification of FOXA2
BACKGROUND The redox-active pyocyanin (PCN) is a toxic, secondary metabolite secreted by the respiratory pathogen Pseudomonas aeruginosa (PA). Previously, we have shown that mouse lungs chronically exposed to PCN develop goblet cell hyperplasia and metaplasia (GCHM) and mucus hypersecretion, fibrosis and emphysema. These pathological features are commonly found in the airways of several chronic...
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The aim of this study was to examine the effects of pyocyanin exposure on mitochondrial GSH, other cellular thiols (thioredoxin-1, Trx-1), and oxidant-sensitive signaling pathways hypoxia inducible factor (HIF-1α) and heme oxygenase (HO-1) in A549 and HBE cell lines. A549 human type II alveolar epithelial cells and human bronchial epithelial (HBE) cells were treated with varying concentrations ...
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ژورنال
عنوان ژورنال: Respiratory Research
سال: 2013
ISSN: 1465-9921
DOI: 10.1186/1465-9921-14-82